They were located in 5 genes (RPS6KA1, ATF6B, HSD17B3, CREB3L1 and SRC), which fell under the estrogen signalling pathway (5 genes), the steroid hormone biosynthesis pathway, the GnRH signalling pathway, the progesterone-mediated oocyte maturation pathway, the prolactin signalling pathway, the oxytocin signalling pathway and the prostate cancer signalling pathway (one gene each). The gene discussed is CREB3L1; the disease is Familial prostate cancer.