Virtually all tumors with this expression pattern possessed co-amplification of a region on 8q22–24 that includes RPL8, RPL30, and the oncogenes MYC and PVT1. Amplification of this region has been previously described in breast cancers and correlates with chemoresistance and metastasis [36, 37, 45–47]. The gene discussed is PVT1; the disease is breast carcinoma.