Among the regulators of the sub-networks the Forkhead family of transcription factors was the most represented with 3 members: FOXO1, FOXO3 and FOXO4. They were respectively identified as regulators of the sub-networks enriched in genes involved in acute myocardial infarction pathway, cancer pathways, neurotrophin signaling and immune system pathway. The gene discussed is BDNF; the disease is myocardial infarction.