To avoid hypoglycaemia due to better compliance with treatment rules at the DRC, total daily insulin dose had to be reduced by 13% from 0.53 (0.44; 0.65) to 0.46 (0.39; 0.53; p Type 1 diabetes patients with cutaneous infiltrations due to monolocal insulin injections (49%) required somewhat higher insulin doses at admission (+19%) than those without lipodystrophy (0.61 (0.47; 0.70) vs. 0.51 (0.42; 0.56) U/kg b.w., p<0.05). The gene discussed is INS; the disease is lipodystrophy.