RLBP1 and Cone rod dystrophy: Previous literature strongly supports a functional connection of each of these two genes to the visual system and their role in retinal disease: RLBP1 is a functional component of the “visual cycle” and mutations in the RLBP1 gene have been associated with autosomal recessive rod-cone dystrophies [21], such as autosomal recessive retinitis pigmentosa [22], Bothnia dystrophy [23,24], Newfoundland rod-cone dystrophy [25], retinitis punctata albescens [26,27], and fundus albipunctatus [26] (S8 Table).