HTRA1 and age-related macular degeneration: By testing the previously established 34 AMD lead variants for age difference (at Bonferroni-corrected significance, PAgediff < 0.05/34), we identified stronger effects among younger individuals for two variants, including the CFH and ARMS2/HTRA1 loci (rs10922109 and rs3750846, PAgediff = 1.36 x 10−3 and 1.04 x 10−3, respectively, Table 1, S1 Table).