These included up-regulation in severe malaria of CIDRα1.1 and CIDRα1.6, which bind EPCR [35] and are often found in DC8 and DC4, respectively [32,34,45,46,48,49]; DBLα2, which is restricted to DC8; and DBLβ12, which binds gC1qR [45] and is invariably found in DC8. This evidence concerns the gene PROCR and malaria.