ICAM1 and cerebral malaria: DBLβ5 from group B var genes and specific motifs in DBLβ1 and DBLβ3 from group A var genes bind intercellular adhesion molecule 1 (ICAM1) [38–42], and cerebral malaria has been associated with ICAM1 binding [43,44] and expression of group A carrying tandem CIDRα1-DBLβ1/3 domains [42].