Because we observed that inflammation can induce Fgf23 mRNA expression in multiple non‐osseous tissues, we next sought to determine potential sources of the CKD‐induced increase in iFGF23 levels and to assess whether the upregulation of these levels of iFGF23 were mediated by the −16kb enhancer of Fgf23. The gene discussed is FGF23; the disease is chronic kidney disease.