Moreover, although we show that both PTH and inflammation can increase Fgf23 levels in bone, only inflammation appears capable of inducing non‐osseous Fgf23 expression, suggesting that the higher Fgf23 levels observed in CKD bones may be due to elevated PTH or inflammation, whereas the increased non‐osseous Fgf23 levels are likely due to increased inflammation. Here, FGF23 is linked to chronic kidney disease.