A number of potent and selective EZH2 and PRC2 inhibitors are being tested in clinical trials in other malignancies where PRC2 activity has demonstrated proto-oncogenic roles such as DLBCL and synovial sarcoma, and it remains to be studied which subsets of AML may benefit from PRC2 antagonist therapies. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.