Co-option of histone methyl and acetyltransferases, such as DOT1L by MLL-fusion proteins has been discussed in detail in the Section “CBP/p300 and MOZ–MORF Fusions.” In addition, a number of AML fusion proteins interfere with functioning of the PRC1 and PRC2 complexes. Here, KAT6B is linked to acute myeloid leukemia.