The ovarian cancer cell line RMG1, which overexpresses FUT1, exhibits elevated protein levels of the integrin adhesion receptor α5β1, upregulation of the matrix metalloproteases MMP-2 and MMP-9 and a concomitant downregulation of the tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 (96). The gene discussed is FUT1; the disease is ovarian carcinoma.