FUT4/Lewisx overexpression is induced by the RAF-MEK-ERK signaling pathway, and colon cancer cells that are FUT4+Lewisx+ seem to exhibit significant resistance to the anti-EGFR (cetuximab) and the anti-VEGF (bevacizumab) chemotherapeutical agents (141). This evidence concerns the gene FUT4 and malignant colon neoplasm.