γ-Synuclein (γ-Syn) and cellular prion protein (PrPC), predominantly expressed in neurons of the brain and implicated in neurodegenerative diseases (Lavedan et al., 1998; Prusiner, 1998), are found to be aberrantly overexpressed in colorectal cancer (Liu et al., 2005; Antonacopoulou et al., 2008). This evidence concerns the gene PRNP and colorectal cancer.