Continuing our research in elucidating the roles of neuronal proteins γ-Syn and PrPC in colorectal cancer cell biology (Yap & Say, 2011, 2012; Chieng & Say, 2015; Goh & Say, 2015), we investigated the angiogenic effects of these two proteins in LS 174T cells by performing in vitro angiogenesis assay. This evidence concerns the gene PRNP and colorectal cancer.