MAX and neoplasm: The peptide mimetic IIA6B17 was first reported as a small-molecule inhibitor of Myc–Max dimerization.15 A compound called 10058-F4 was capable of disrupting the Myc–Max complex in HL60 cells.56 Another widely known inhibitor, Omomyc, a mutant basic helix-loop-helix peptide that sequesters Myc in a transcriptionally incompetent complex, prevents Myc-induced tumorigenesis in multiple mouse tumor models.57–59