FGF2 and neoplasm: According to one recent study, tumor cell-derived ECs were refractory to inhibition of both the VEGF-A and basic fibroblast growth factor (bFGF and FGF-2) pathways.9 In fact, it is well established that tumor endothelial cells participate in the recruitment of stromal cells, including myeloid cells and bone marrow-derived cells, to generate a VEGF-A-independent pathway of tumor resistance to antiangiogenic treatment.27 Angiogenesis inhibitors block outside tumor vessels from growing into the solid tumor, thus terminating the supply of nutrients feeding tumor growth.