Inhibition of BMP, Notch, and Wnt signaling pathways greatly decreases the generation of kdrl+ cells and expression of ETV2, while overexpression of Etv2 in ES cells rescues the generation of kdrl+ cells.29 All these signaling pathways are active and critically implicated in tumor stem cell fate determination during the pathological progression of GBM.30, 31 As a transcription factor, ETV can be difficult to target. The gene discussed is ETV2; the disease is neoplasm.