EGFR belongs to the HER family of tyrosine kinase, which is widely distributed on the surface of mammalian cell membranes.35 EGFR plays an important role in the etiology and progression of many carcinomas, including HCC.36,37 Here we found that the proliferation and colony formation of Hep3B and Huh7 cells were markedly inhibited when EGFR was silenced, and the suppressive tumorigenic property of miR-338-5p was mostly restored when EGFR was overexpressed in these HCC cells. This evidence concerns the gene EGFR and carcinoma.