MicroRNAs (miRNAs) are small endogenous non-coding RNAs with 18–25 nucleotides that can trigger either mRNA translational suppression or mRNA degradation.12 Multiple miRNAs are capable of modulating MDR in cancers.13,14 Zhu et al.15 found that miR-181b modulated multidrug resistance by targeting BCL2 in human cancer cell lines. This evidence concerns the gene BCL2 and cancer.