IL2 and type 1 diabetes mellitus: Yenkel Grinberg-Bleyer et al.74 found that 5 days of low-dose IL-2 administration starting at the time of T1D onset can reverse established disease in NOD mice, with long-lasting effects by increasing the numbers of Treg cells in the pancreas and inducing expression of Treg related proteins including Foxp3, CD25, CTLA-4, ICOS, and GITR in these cells.