Predictors associated with increased risk of hypoglycemia in one or both models included increasing basal insulin doses (in range of ≤0.8 units/kg), increasing nutritional insulin doses (in range of ≤0.6 units/kg), use of high-dose SSI, higher index day and admission CVBG, NPO diet, type 1 diabetes/pancreatectomy, type 2 diabetes, CKD, and digestive diseases. The gene discussed is INS; the disease is type 2 diabetes mellitus.