In this sense, VHSV halted infection in rainbow trout RBCs did not seem to be related to IFN1 or IFN1-inducible genes, sinceinf1,mx andpkr genes as well as Mx and IFN1 proteins appeared poorly modulated or downregulated during VHSV exposure, in contrary to the 8-fold increase in ISAV productive infection in salmon RBCs7, the 50-fold increases in PRV productive infection in salmon RBCs5 or the 50-fold increases in IPNV non-productive infection in rainbow trout RBCs71. Here, MX1 is linked to infection.