GRIK2 and chronic obstructive pulmonary disease: While TRPV3 showed a non-significant trend toward increased gene expression in cells isolated from individuals with COPD (p = 0.0618 Welch’s t test, Fig. 5a), both OAT (p = 0.0109 Welch’s t test, Fig. 5b) and GRIK2 (p = 0.0358 Welch’s t test, Fig. 5c) showed a significant increase in gene expression in cells isolated from individuals with COPD versus those without COPD.