TNFAIP3 and the NR4A family, including NR4A1, NR4A2, and NR4A3, represent a group of potent inhibitors of NF-kB pathway (56, 57), whose deregulation has been associated to several chronic inflammatory and autoimmune conditions including MS (58, 59). Here, NR4A3 is linked to myeloid sarcoma.