Numerous candidate genes have been associated with risk of TB, including members of the toll-like receptor (TLR) family (TLR1, TLR2, TLR4, TLR6, TLR9, TLR10, TIRAP) (7–9), which are widely expressed on various immune cells including monocytes, macrophages, dendritic cells, and lymphocytes and may modulate activation via TLR ligands (10, 11). The gene discussed is TLR2; the disease is tuberculosis.