Notably, interaction of EPCR with its ligand the activated protein C (APC) has a role in anti-inflammatory, coagulation homeostasis, and endothelial barrier protection functions (62) and its blockade of these functions by PfEMP1–EPCR interaction that is postulated to contribute to cerebral malaria pathology (59, 61). The gene discussed is PROCR; the disease is cerebral malaria.