Of the 25 inflammation-related factors that were regulated in human NASH, 18 were also affected in HFD-fed Ldlr−/−.Leiden mice, including the pathways downstream of the cytokines TNF, TGFB1 and CSF2 which were activated in both human and murine NASH. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.