TP53 and neoplasm: Both chaperones HSP70 and 90 have been implicated to interfere with apoptotic pathways, e.g., in human tumors, and recently overexpression of HSP90 and its interaction with the p53 tumor suppressor protein (or its mutant variants) has been shown to enhance intensity of hemolymphatic neoplasia in cockles (Díaz et al., 2011).