At the cellular level, the major hallmarks of AD are the formation of Aβ plaques and NFTs of hyperphosphorylated tau protein that can be observed specially in the basal forebrain, frontal lobe, hippocampus and cerebral cortex of both human cases and animal models (Duyckaerts et al., 2009; De-Paula et al., 2012; Taipa et al., 2012; Armstrong, 2014; Garin et al., 2015). The gene discussed is MAPT; the disease is Alzheimer disease.