Activation of PPARγ ameliorates monocrotaline-induced PASMC proliferation and vascular remodeling in a rat model of PAH by stimulation of expression of PTEN and inhibition of the phosphatidylinositide 3-kinase/protein kinase B(PI3K/Akt) pathway (Xie et al., 2015). This evidence concerns the gene PTEN and pulmonary arterial hypertension.