Neuropathologically, AD is marked by extracellular amyloid plaques, composed of beta-amyloid1−42 (Aβ42) peptides, intracellular neurofibrillary tangles (NFTs), containing tau proteins, and both synaptic and neuronal loss (Yaari and Corey-Bloom, 2007). This evidence concerns the gene MAPT and Alzheimer disease.