In the year 2004, Lwin et.al firstly identified a higher rate of GBA mutations, either heterozygous or homozygous (N370S, L444P, K198T, and R329C), in brain samples from PD patients, which indicated a possible relationship between GBA mutations and the disease (Lwin et al., 2004). The gene discussed is GBA1; the disease is Parkinson disease.