Two homologues of oestrogen receptors (ERs), ERα and ERβ, have different distribution and function among normal tissues as well as neoplasms including stomach cancer.15 Propylpyrazole triol (ERα agonist) showed the similar cytotoxicity against the GE and GC cell lines, whereas diarylpropionitrile (ERβ agonist) specifically killed the GC, suggesting that ERβ could mainly mediate cell death of the GC cell lines. The gene discussed is ESR2; the disease is gastric neoplasm.