To investigate the relationship between gender, histological subtype, E-cadherin/p53 status and prognosis in clinical samples of GC, we used public data provided from the Cancer Genome Atlas Research Network (TCGA), which included 176 tumours (76 DGC and 100 IGC) with gene mutation, copy number alteration, DNA methylation, mRNA expression and pathological data. Here, TP53 is linked to neoplasm.