While Dyssegmental dysplasia Rolland Desbuquois type is considered the milder spectrum of DD, it is unclear at this time if this condition is related to HSPG2, as mutations in HSPG2 have not been reported so far in DDRD patients (McKusick, 1986). This evidence concerns the gene HSPG2 and dyssegmental dysplasia, Rolland-Desbuquois type.