Based on somatic mutations detected by sorted cell sequencing, TP53, EGFR, PTEN, RB1, KRAS, CTNNB1, GNAQ, SMAD4, IDH1, CDKN2A, APC, PIK3CA, HRAS, and NRAS were observed significantly in 22 lung adenocarcinomas (Fig. 5). This evidence concerns the gene HRAS and lung adenocarcinoma.