Given the current limited evidence and the important clinical and costs implications, the main objective of this study was to provide real-world evidence on treatment patterns for T2DM GLP-1 RA therapy initiators in Italy, specifically persistence with the GLP-1 RA (i.e., index therapy) and treatment modifications, including discontinuation, switch to another hyperglycemic therapy, dosing changes and augmentation (addition of new therapy to the index treatment). This evidence concerns the gene GLP1R and type 2 diabetes mellitus.