TRPM2 and cancer: Plasma membrane located at the migration front in HeLa and PC3 cells, both cancer cell lines, are provided with TRPM2 channels that sense local H2O2 and allow Ca2+ influx and accumulation of Zn2+ at this region, which according to the authors represents a novel role for Zn2+ in cellular migration that antagonizes the well-known role of Ca2+[30].