A previous study has demonstrated that tanshinone IIA played a significant role in reducing infarct size, improving heart function and increasing the survival rate of rats with MI.17 In addition, sodium tanshinone IIA sulphonate has shown to prevent cardiac remodelling in animal models of acute MI.18 However, whether or not tanshinone IIA has any neuroprotective effects or not in LVR after MI via the TLR4/MyD88/NF‐κB signalling pathway still remains unknown. This evidence concerns the gene NFKB1 and myocardial infarction.