Considering that activated caspase‐3 signalling is involved in β‐cell apoptosis in islets of animals and humans with T2DM 42, liraglutide may well reflect the action of GLP‐1, as GLP‐1R activation leads to inhibition of caspase activation and increased survival of β‐cells 17, 47. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.