MICAL1 and breast cancer: Cyclin D is regulated by the upstream pathways including NF‐κB, PI3K/Akt/mTOR and Wnt/β‐catenin.22, 23, 24, 25, 26 MICAL1 has an important role in triggering Akt phosphorylation, which is a key signal that can endow breast cancer cells with an invasive phenotype.17 We have noticed that MICAL1 selectively activates PI3K/Akt signalling pathway.