FAD domain contains flavin mono‐oxygenase activity and is responsible for majority of MICAL1's function.9 Recently, overexpression of MICAL2 and MICAL‐L2, the other members of MICAL family, has been confirmed to be related to multiple invasive phenotype of cancer cells such as increased motility, proliferation, as well as inducing epithelial‐to‐mesenchymal transition (EMT).10, 11 Domain architecture of MICAL1 is closely related to Drosophila MICAL4; however, to date, only a few reports characterizing the functions of MICAL1 in human cancer progression have been published. This evidence concerns the gene MICAL2 and cancer.