PI3K/Akt and ERK are particularly sensitive to redox reaction.28, 30 Additionally, ROS scavenger NAC significantly reversed MICAL1 overexpression induced up‐regulation of p‐Akt and p‐Akt inhibitor LY294002 significantly reversed MICAL1 overexpression induced up‐regulation of p‐ERK, CDK4 as well as cyclin D in breast cancer cells. The gene discussed is CDK4; the disease is breast cancer.