AKT1 and melanoma: Recent immunohistochemical studies revealed that MICAL1 is highly expressed in hBRAFV600E human melanomas which display constitutive activation of the AKT, ERK pathway and abnormal melanoma growth.5 MICAL1 has been identified exert its effect on promoting breast cancer cell invasion with RAB protein.17 In this study, we will address the role of MICAL1 in breast cancer cell proliferation and provide evidence for a mechanism describing its regulation.