MICAL1 and breast carcinoma: Among the members of the MAPK family, extracellular signal‐regulated protein kinase (ERK) can alter the level and activity of transcription factor c‐myc, leading to changes in cyclin D transcription that are mainly responsible for cell cycle.27 Phosphorylation of ERK and its translocation to nucleus by ROS have been proven to be an important mechanism to mediate breast cancer cell migration by LPA.28 We detected an up‐regulation of p‐ERK in the nucleus upon MICAL1 expression.