Large, real-world studies conducted in Asia, such as The First Basal Insulin Evaluation (FINE) Asia registry study and the Observational Registry of Basal Insulin Treatment (ORBIT) study, have hypothesized that further active titration of basal insulin can potentially increase the proportion of patients with T2DM achieving adequate glycemic control and improve glycemic outcomes [9, 14]. This evidence concerns the gene INS and type 2 diabetes mellitus.