LEP and metabolic dysfunction-associated steatohepatitis: In C57BL/6 mice fed a 60% high-fat diet to generate non-alcoholic steatohepatitis, oleuropein (0.05% diet) over 6 months improved HOMA-IR and leptin levels [8], while serum glucose and cholesterol levels in alloxan-induced diabetic rats were decreased by oleuropein (8 and 16 mg/kg body weight) after 4 weeks [30].