In order to test a possible direct cross-talk between TRPV2-dependent calcium entry and CFTR ion transport activity, we pharmacologically inhibited CFTR function in non-CF macrophages by CFTRinh-172 (10 μM, 72 h), often used at this concentration in that context17,18,26–28. The gene discussed is TRPV2; the disease is cystic fibrosis.