KRT16 and epidermolytic palmoplantar keratoderma, 1: Oxidative stress has been linked previously to palmoplantar keratoderma associated with Keratin 16 (K16) mutations, and the use of SFN (Sulforaphane), a natural isothiocyanate compound found in cruciferous vegetables, rescued the palmoplantar keratoderma phenotype in krt16−/− mice28.