CBFB and HIV infectious disease: CBFβ has been reported to be hijacked by HIV Vif protein to degrade APOBEC3G and promote HIV infection.22 To study the regulation of CBFβ in response to HBV infection, with polydAdT and polyIC as controls, we found that CBFβ was significantly upregulated in HepG2 cells transfected with the HBV whole-genome expression plasmid (pHBV1.3; Fig. 1a) and that it was downregulated in a time-dependent manner (Fig. 1b).