RRM1 and pancreatic adenocarcinoma: In a study from Cleveland, Xie et al.17 found that intratumoural RRM1 mRNA expression did not have significant prognostic value in 122 patients who had had resection for pancreatic adenocarcinoma, whereas low RRM1 expression was associated with longer overall survival in the 44 patients who had received adjuvant gemcitabine.