PTEN and prostate neoplasm: Consistent with the results of Pten deletion in the cell culture model (Fig 6A), Akt phosphorylation level was robustly increased in the prostates of Ptenpc−/− mice compared with Pten‐positive controls, while Hdac3 loss significantly diminished AKT phosphorylation in prostate tumors with Ptenpc−/− background (Fig 6B‐iii).