Notably, ectopic expression of F133V (a hotspot mutation of SPOP) in human prostate cancer cells or knock‐in of this mutant in the mouse prostate results in an abnormal activation of AKT‐mTORC1 signaling (Blattner et al, 2017; Zhang et al, 2017). This evidence concerns the gene AKT1 and Familial prostate cancer.