Individuals with at least 1 copy of the ε4 allele are at higher risk of Alzheimer disease108 and worse outcomes after traumatic brain injury.109 In patients with CHD, the ApoE ε2 allele is associated with worse early ND performance in patients with CHD,110 a deficit that persists as patients age111 and that has been replicated in a similar but distinct patient cohort.112 It has been proposed that ApoE allele status affects neuroresiliency and that the ApoE ε2 allele renders patients less resistant to neuroinjury that may occur in utero or perioperatively in patients with CHD. This evidence concerns the gene APOE and coronary artery disorder.