Examples include mutations in MYH7 (β myosin heavy chain) in individuals with Ebstein anomaly of the tricuspid valve, in ACTC1 (cardiac α actin) in familial ASD, and in MYH6 (α myosin heavy chain 6) in autosomal dominant familial ASD and sporadic cases of more complex CHD, including Shone complex and HLHS.35 There is mounting evidence that genetic variation in sarcomeric genes can concurrently cause CHD and affect ventricular function. Here, MYH6 is linked to atrial septal defect.