Microdeletions of chromosome 8p23.1 are uncommon in the general population but can be found in a significant number of patients with CHD due to the loss of the GATA4 gene, a transcription factor critical to heart development.71 In addition to cardiac defects, dysmorphic facies, short stature, and developmental delay are common features of 8p23.1 deletion syndrome.72 This evidence concerns the gene GATA4 and coronary artery disorder.