In agreement with recent reports comparing individualized and conventional COS [3, 4], most clinicians use ovarian reserve markers like antral follicle count (AFC) and/or Anti-Müllerian hormone (AMH) for clinical decision-making to tailor the most optimal individualized controlled ovarian stimulation (iCOS) strategy, securing the shortest time to pregnancy and live birth as well as a low risk of ovarian hyperstimulation syndrome (OHSS) development [5]. This evidence concerns the gene AMH and ovarian hyperstimulation syndrome.