Recently, our lab has clarified that CSM [Ca2+]i handling dysfunction occurs in a biphasic manner during CAD progression, with SR Ca2+ store capacity and sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) function being upregulated in early, mild CAD and downregulated in late, more severe CAD [18]. Here, ATP2A3 is linked to coronary artery disorder.