The role of Ire1/Xbp1 signalling pathway in MCDS pathology was shown to be of little biological importance, as chondrocyte-specific ablation of Xbp1 in MCDS mice (Col10a1 p.N617K) did not alter the disease severity in MCDS [9]. The gene discussed is XBP1; the disease is Schmid metaphyseal chondrodysplasia.