As shown in Fig 1A, shRNA-mediated knockdown of SR-A6 in MPI-2 cells significantly reduced GFP transgene expression from the non-replicating HAdV-C5_dE1_GFP vector, whereas no reduction in infection efficiency was observed upon knockdown of other scavenger receptors expressed in MPI-2 cells, i.e. SR-A1 (Msr1), SR-B1 (SCAR-B1) or SR-B2 (CD36). The gene discussed is MSR1; the disease is infection.