Because of the complexity of recommended medication for hypertension with numerous potential permutations, and because of the difficult in distinguishing their clinical indications in an individual (as when a diuretic or a beta blocker might have been prescribed for reasons other than hypertension) we did not include antihypertensives in this analysis, although we analysed the use of ACE inhibitors in relation to stable angina with diabetes, unstable angina, and MI. The gene discussed is ACE; the disease is hypertensive disorder.