Delivery of exogenous oxysterols to NPC fibroblasts[35] and lysosomal cholesteryl ester to CESD fibroblasts[34] were both able to upregulate ABCA1 expression and cholesterol efflux to apoA1, suggesting that cytosolic cholesterol is a critical determinant of cholesterol-dependent ABCA1 gene regulation. The gene discussed is ABCA1; the disease is nasopharyngeal carcinoma.