TP53 and breast cancer: In addition to BRCA1 and BRCA2, eight genes were defined as “core genes” based on data available at the time of the gene panel design, that suggested their association with BC (ATM, CDH1, CHEK2, NBN, PALB2, and TP53) or OC (RAD51C and RAD51D) 10, 11, 12, 13.