TP53 and breast cancer: In a gene‐specific analysis, only patients carrying deleterious TP53 variants showed a younger mean age at first BC diagnosis (TP53: 39.7 years, range 23–71 years) compared with the overall sample (46.7 years, range 17–92 years), with differences reaching levels of significance (P = .004, Student's t‐test, Table 4).