NHERF1 and cancer: While ezrin and NHERF proteins have important roles in the organization of cell membrane domains and cell–cell and cell–extracellular matrix (ECM) communication 41, our studies reveal that ezrin/NHERF1 interaction is fundamental to morphogenic trajectories involving epithelial shape, configuration, spatial rearrangements, and luminogenesis in physiological and cancer states through control of bipolar mitotic spindle orientation.